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use crate::sketchbook::ids::VarId;
use crate::sketchbook::model::{Essentiality, Monotonicity};
use serde::{Deserialize, Serialize};
use std::fmt::{Display, Error, Formatter};
use regex::Regex;
/// **(internal)** A regex string of an identifier which we currently allow to appear.
/// This regex does not enforce beginning/ending as it is used inside of larger regulation
/// regex.
const ID_REGEX_STR: &str = r"[a-zA-Z_][a-zA-Z0-9_]*";
/// **(internal)** Regex which matches the regulation arrow string with `regulation_sign`
/// and `essential` groups.
const REGULATION_ARROW_REGEX_STR: &str = r"-(?P<regulation_sign>[|>?*])(?P<essential>X|\?|)";
lazy_static! {
/// **(internal)** A regex which reads one line specifying a regulation.
static ref REGULATION_REGEX: Regex = Regex::new(
format!(
// regulator ID, whitespace?, arrow string, whitespace?, target ID
r"^(?P<regulator>{})\s*{}\s*(?P<target>{})$",
ID_REGEX_STR,
REGULATION_ARROW_REGEX_STR,
ID_REGEX_STR,
).as_str()
).unwrap();
}
/// Describes an interaction between two variables, `regulator` and `target`.
/// Every regulation can be *monotonous* and can be set as *essential*:
///
/// Monotonicity is `positive`, `negative`, `dual`, or `unknown`. The monotonicity signifies how
/// the presence of the `regulator` affects the value of the `target`:
/// - if the regulation is `positive`, it might only *increase* the `target` value
/// - if the regulation is `negative`, it might only *decrease* the `target` value
/// - if the regulation is `dual`, it might both *increase* or *decrease* the `target` value (in
/// different contexts)
///
/// If essentiality is set to *true*, the `regulator` *must* have influence on the outcome
/// of the `target` update function in *some* context. If set to `False`, this regulation must have
/// no effect. If it is `Unknown`, the essentiality is not enforced (i.e. the `regulator` *can*
/// have an influence on the `target`, but it is not required).
///
/// Regulations can be represented as strings in the
/// form `"regulator_name 'relationship' target_name"`. The 'relationship' starts with `-`, which
/// is followed by `>` for activation (positive monotonicity), `|` for inhibition (negative
/// monotonicity), `*` for dual effect (non-monotonic) or `?` for unspecified monotonicity.
/// Finally, an additional `X`, `?` at the end of 'relationship' signifies that the the regulation
/// is non-essential (non-essential) or the essentiality is unknown, respectively.
/// Together, this gives the following options: `->, ->?, -|, -|?, -*, -*?, -?, -??`.
#[derive(Clone, Debug, Eq, Hash, PartialEq, Serialize, Deserialize)]
pub struct Regulation {
regulator: VarId,
target: VarId,
essential: Essentiality,
regulation_sign: Monotonicity,
}
/// Methods for safely generating new `Regulations`.
impl Regulation {
/// Create new `Regulation` given all the components.
pub fn new(
regulator: VarId,
target: VarId,
essential: Essentiality,
regulation_sign: Monotonicity,
) -> Regulation {
Regulation {
regulator,
target,
essential,
regulation_sign,
}
}
/// Try to read the regulation from a given string in the standard format.
/// Returns error if the string is invalid.
pub fn try_from_string(regulation_str: &str) -> Result<Regulation, String> {
let (regulator, regulation_sign, essential, target) =
Regulation::try_components_from_string(regulation_str)?;
Ok(Regulation {
regulator: VarId::new(regulator.as_str())?,
target: VarId::new(target.as_str())?,
regulation_sign,
essential,
})
}
/// Try to read all available information about a regulation from a given string
/// in the standard format.
///
/// The returned data correspond to the items as they appear in the string, i.e. `regulator`,
/// `regulation_sign`, `essentiality` and `target`. If the string is not valid, returns `None`.
pub fn try_components_from_string(
regulation_str: &str,
) -> Result<(String, Monotonicity, Essentiality, String), String> {
REGULATION_REGEX
.captures(regulation_str.trim())
.map(|captures| {
let regulation_sign = match &captures["regulation_sign"] {
"|" => Monotonicity::Inhibition,
">" => Monotonicity::Activation,
"*" => Monotonicity::Dual,
"?" => Monotonicity::Unknown,
_ => unreachable!("Nothing else matches this group."),
};
let essential = match &captures["essential"] {
"" => Essentiality::True,
"X" => Essentiality::False,
"?" => Essentiality::Unknown,
_ => unreachable!("Nothing else matches this group."),
};
(
captures["regulator"].to_string(),
regulation_sign,
essential,
captures["target"].to_string(),
)
})
.ok_or(format!("Regulation string is invalid: {regulation_str}"))
}
}
/// Basic getters and other non-modifying methods.
impl Regulation {
/// Check if the regulation is marked as essential.
///
/// Note that both negative or unknown essentiality results in `false`.
pub fn is_essential(&self) -> bool {
self.essential == Essentiality::True
}
/// Get the essentiality of the regulation.
pub fn get_essentiality(&self) -> &Essentiality {
&self.essential
}
/// Get the sign of the regulation.
pub fn get_sign(&self) -> &Monotonicity {
&self.regulation_sign
}
/// Get the `VarId` of the regulator.
pub fn get_regulator(&self) -> &VarId {
&self.regulator
}
/// Get the `VarId` of the target.
pub fn get_target(&self) -> &VarId {
&self.target
}
}
/// Methods for editing `Regulations`.
impl Regulation {
/// Directly swap original regulator with a given one.
pub fn swap_regulator(&mut self, new_regulator: VarId) {
self.regulator = new_regulator;
}
/// Directly swap original target with a given one.
pub fn swap_target(&mut self, new_target: VarId) {
self.target = new_target;
}
/// Directly swap original sign with a given one.
pub fn swap_sign(&mut self, new_sign: Monotonicity) {
self.regulation_sign = new_sign;
}
/// Directly swap original essentiality with a given one.
pub fn swap_essentiality(&mut self, new_essentiality: Essentiality) {
self.essential = new_essentiality;
}
}
impl Display for Regulation {
/// Standard format that can be parsed back.
fn fmt(&self, f: &mut Formatter<'_>) -> Result<(), Error> {
let regulation_sign = self.get_sign().to_string();
let essentiality = match self.get_essentiality() {
Essentiality::True => "",
Essentiality::False => "X",
Essentiality::Unknown => "?",
};
write!(
f,
"{} -{}{} {}",
self.regulator, regulation_sign, essentiality, self.target
)
}
}
#[cfg(test)]
mod tests {
use crate::sketchbook::model::{Essentiality, Monotonicity, Regulation};
#[test]
fn regulation_conversion() {
let regulation_strings = vec![
"a -?? b", "b -? c", "c ->? d", "d -> e", "e -|? f", "f -| g", "g -*? h", "h -* i",
];
let regulators = vec!["a", "b", "c", "d", "e", "f", "g", "h"];
let targets = vec!["b", "c", "d", "e", "f", "g", "h", "i"];
let essentiality = vec![
Essentiality::Unknown,
Essentiality::True,
Essentiality::Unknown,
Essentiality::True,
Essentiality::Unknown,
Essentiality::True,
Essentiality::Unknown,
Essentiality::True,
];
let regulation_sign = vec![
Monotonicity::Unknown,
Monotonicity::Unknown,
Monotonicity::Activation,
Monotonicity::Activation,
Monotonicity::Inhibition,
Monotonicity::Inhibition,
Monotonicity::Dual,
Monotonicity::Dual,
];
for i in 0..regulation_strings.len() {
let regulation = Regulation::try_from_string(regulation_strings[i.clone()]).unwrap();
assert_eq!(regulation.to_string().as_str(), regulation_strings[i]);
assert_eq!(regulation.regulator.as_str(), regulators[i.clone()]);
assert_eq!(regulation.target.as_str(), targets[i.clone()]);
assert_eq!(regulation.regulation_sign, regulation_sign[i.clone()]);
assert_eq!(regulation.essential, essentiality[i.clone()]);
}
assert!(Regulation::try_from_string("a --> b").is_err());
assert!(Regulation::try_from_string("-a -> b").is_err());
assert!(Regulation::try_from_string("a - b").is_err());
}
}